The bigger the save, the higher the chances get that you'll see a number of really lame issues like corrupted saves, unreasonable load times, crashes while saving, etc. The more mods you have, the bigger the save. When you save your game, it has to write the state of not only the game, but all the stuff you've modded into it, into that save. That isn't how game engines work, and that isn't how memory works. You can't just keep piling more and more and more and more and more onto a game and say 'deal with it'. Its a matter of managing data, memory usage and savegame file size. No offense, Yeezus, but the 'mod limitation' isn't because of some evil developer imposing their will/dictatorship upon you.
